The existing state-of-the-art DIA-MS informatics algorithms
* quantify only what they identify, but
* only identify what is in FASTA search space
The GoldenHaystack algorithm does not use the FASTA file, and can therefore quantify all the peptides in one's MS (i.e., the dark proteome). This is a far more transformational change than may be apparent at first glance.
The existing state-of-the-art DIA-MS informatics algorithms
* quantify only what they identify, but
* only identify what is in FASTA search space
The GoldenHaystack algorithm does not use the FASTA file, and can therefore quantify all the peptides in one's MS (i.e., the dark proteome). This is a far more transformational change than may be apparent at first glance.
